Trihexyphenidyl (Artane ®)
Clinicians are increasingly recognizing the presence of dystonia in cerebral palsy. In fact, dystonia can be more disabling than spasticity as it is triggered or increased by attempted voluntary movements, interfering with fine and gross motor activities, communication and ease of care. Because dystonia is often exacerbated by movement and emotional state, severity often varies with body position, motor tasks, or mood. Thus, treatment is challenging. The most commonly used medication for children with dystonia is trihexyphenidyl (Artane). Treatment with trihexyphenidyl sometimes requires very high doses in some children. If the dose is raised very slowly, children seem to tolerate the medicine with relatively few side effects.
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